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Isothermal Amplification Breakthrough: RAA Platform Accelerates Chikungunya Virus Research
Release date:
2025-05-07
Since 2025, Chikungunya virus (CHIKV) has shown exceptionally active spread in tropical regions. Although traditional RT-PCR offers high sensitivity, its >2-hour amplification cycle and heavy reliance on specialized equipment have created bottlenecks for research teams needing critical data during outbreaks. Field traceability studies are further constrained by cold-chain transport requirements and laboratory dependencies.
Epidemic Research Faces Timeliness Challenges
Since 2025, Chikungunya virus (CHIKV) has shown exceptionally active spread in tropical regions. Although traditional RT-PCR offers high sensitivity, its >2-hour amplification cycle and heavy reliance on specialized equipment have created bottlenecks for research teams needing critical data during outbreaks. Field traceability studies are further constrained by cold-chain transport requirements and laboratory dependencies.
Limitations of Current Detection Technologies:
● Virus Isolation: Time-consuming, labor-intensive, and incompatible with rapid screening
●Serological Diagnosis: Low sensitivity for early-stage infections, leading to missed cases
●RT-PCR: Requires expensive thermal cyclers and advanced labs; lacks portability
●RT-LAMP: Needs multiple primers and suffers from poor specificity
●NASBA: Lengthy 2-hour reaction time
Revolutionary Isothermal Amplification Technology
RAA technology, short for Recombinase Aided Amplification,is a technology that utilizes recombinase, single-stranded binding protein and DNA polymerase to perform nucleic acid amplification under isothermal conditions (the optimal temperature is 39℃).The specific principle is: Recombinases, single-stranded binding proteins, and primers form polymers to scan double-stranded DNA, unwind double-stranded DNA at sequences homologous to the primers, and single-stranded binding proteins (SSBS) bind to the untwisted single strand to prevent single-stranded DNA refolding. In the presence of
energy and dNTP, DNA polymerase completes the strand extension and repeats the process. The amplification can be detected by the instrument within 5-15 minutes.
Compatible detection methods include:
→ Electrophoresis Method
→ Test Strip Method
→ Fluorescent Method
RAA Scientifi Research Platform Kit：
RAA Research Platform Kit Features:
Academic Impact Validation
Supported by 190+ international journal publications:
Certified Institutional Partners
→ Sierra Leone-China Friendship Laboratory (Malaria Surveillance)
→ CDC (Emerging Virus Screening Systems)
→ Leipzig University, Germany
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