Core Technology
core technology
Recombinase-mediated isothermal nucleic acid amplification technology
RAA technology stands for Recombinase-Aided Amplification, a recombinase-mediated isothermal nucleic acid amplification technique. It leverages the combined action of recombinase, single-strand binding protein, and DNA polymerase to amplify nucleic acids under isothermal conditions—at an optimal temperature of 39°C. The underlying principle involves the formation of a complex where recombinase, single-strand binding protein, and primers work together to scan double-stranded DNA. At sequences complementary to the primers, this complex unwinds the double helix. The single-strand binding protein (SSB) then stabilizes the exposed single strands, preventing them from reannealing. In the presence of energy and dNTPs, DNA polymerase takes over, extending the newly synthesized strands. This process cycles repeatedly, enabling detection of the amplified product by instrumentation within just 5 to 15 minutes.
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